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Natural Sciences and Mathematics | Biological Sciences Master's Theses

A collection of master's theses from the Biological Sciences program in the Department of Natural Sciences and Mathematics at Dominican University of California.

Theses/Capstones from 2022 2022

Evaluating the Brain-enhancing Mitohormesis of N-Propargylglycine, a Suicide Inhibitor of Proline Dehydrogenase, to Offset the Proteotoxic Mechanisms Underlying Neurodegeneration in Huntington’s Disease And Evaluating the Phenotype of a Mutant Pdia3 Knock-in Mouse Line as a Novel Genetic Model of Neurological Disorders, Fadzai Teramayi

Mapping Natural Genetic Variants Associated with Nutrient Response, Kenneth Wilson

Theses/Capstones from 2021 2021

Growth suppression of ERBB2-driven breast cancers by p300/CBP inhibition, Sergelen Ariunbaatar

Novel small-molecule modifiers rescue pathology associated with NGLY1 Deficiency in a Caenorhabditis elegans model, Michael Broussalian

Distribution and Frequency of Aquatic Oomycetes Throughout Marin County in Relation to Physical Chemical Water Parameters, Franki Crites

Exploring the Relationship Between Cellular Senescence, Apolipoprotein E, and Alzheimer’s Disease, Buay Deng

Analysis of symptom expressions and transmission rates caused by the plant pathogen Phytophthora ramorum on native chaparral plants from the genus Arctostaphylos, Bharati Gaonker

Characterizing markers of Ovarian Health: Implications for Investigating Premature Ovarian Failure in Galactosemia, Alyssa Gonzalez

Understanding the Role of Protein Kinase C and Striatum Development in Huntington’s Disease, Melia Granath-Panelo

Neurogenesis and Neuroprotection in Huntington Disease, Bachir Hadid

Determining the role of methylglyoxal (MGO) and the TRPA1 channel in inducing astrocyte senescence and neurodegeneration, Natalie Hill

Fungi Associated with Herbaceous Plants in Coastal Northern California, Greg Huffman

Mechanisms of how diet and light interact to influence Drosophila longevity through the eye, Charles H. Lau

Advancing the Preclinical Development of Secondary Metabolites from Cacospongia mycofijiensis for the Treatment of Cancer, Joseph Morris

Expanding the understanding of viral tropism by characterizing the N-glycomic profiles of transducible cell lines and tissue types and Characterizing functional receptors that mediate the inhibitory relationship between 4-O-sulfated chondroitin sulfate and neurons, Jorden Tahquechi

Investigating the Human-mouse Interspecies Barrier to AAV-driven Gene Therapy Using a Mouse with a Humanized Liver, Slesha Thapa

Theses/Capstones from 2020 2020

Neuroprotection against Alzheimer’s and lifespan extension induced by dietary restriction are associated with metabolomic changes and depend on oxidative resistance protein 1 (OXR1), George W. Brownridge III

Identifying New Markers and Mechanisms of Mitochondrial Defect During Aging, Catherine Chang

Elucidating the Effects of Glucose Toxicity on Tauopathy and Aging, Lukas Fluitt

Model Characterization of Pulmonary Arterial Hypertension: Analysis of Lung Pathology with Respect to Human Disease, Eptisam Lambu

Modulating Matrix Metalloproteases and Inflammation in Huntington’s Disease, Alejandro Lopez Ramirez

NF-L as a Readout for Disease Progression and Rescue, Isaac Villalpando

Determining the link between advanced glycation endproducts (AGEs), feeding, and metabolism, Lauren Wimer

Theses/Capstones from 2019 2019

GM2 Gangliosidosis Natural History Study: Sandhoff Feline and Tay-Sachs Sheep And Evaluation of different bead coupling chemistries for immobilizing GAG chains to produce affinity resins to discover GAG-binding proteins important for neuroregeneration after central nervous system injury, Catlyn Cavender

Characterizing the sphingosine kinase and sphingosine-1-phosphate pathway in pulmonary arterial hypertension, Alyssa Lanza