A collection of master's theses from the Biological Sciences program in the Department of Natural Sciences and Mathematics at Dominican University of California.

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Theses/Capstones from 2022

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Characterizing the Natural History of Liver Pathology in the Alpha 1 Antitrypsin Deficiency Mouse Model, Selma Takajjart

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Evaluating the Brain-enhancing Mitohormesis of N-Propargylglycine, a Suicide Inhibitor of Proline Dehydrogenase, to Offset the Proteotoxic Mechanisms Underlying Neurodegeneration in Huntington’s Disease And Evaluating the Phenotype of a Mutant Pdia3 Knock-in Mouse Line as a Novel Genetic Model of Neurological Disorders, Fadzai Teramayi

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Mapping Natural Genetic Variants Associated with Nutrient Response, Kenneth Wilson

Theses/Capstones from 2021

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Growth suppression of ERBB2-driven breast cancers by p300/CBP inhibition, Sergelen Ariunbaatar

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Novel small-molecule modifiers rescue pathology associated with NGLY1 Deficiency in a Caenorhabditis elegans model, Michael Broussalian

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Distribution and Frequency of Aquatic Oomycetes Throughout Marin County in Relation to Physical Chemical Water Parameters, Franki Crites

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Exploring the Relationship Between Cellular Senescence, Apolipoprotein E, and Alzheimer’s Disease, Buay Deng

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Analysis of symptom expressions and transmission rates caused by the plant pathogen Phytophthora ramorum on native chaparral plants from the genus Arctostaphylos, Bharati Gaonker

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Characterizing markers of Ovarian Health: Implications for Investigating Premature Ovarian Failure in Galactosemia, Alyssa Gonzalez

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Understanding the Role of Protein Kinase C and Striatum Development in Huntington’s Disease, Melia Granath-Panelo

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Neurogenesis and Neuroprotection in Huntington Disease, Bachir Hadid

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Determining the role of methylglyoxal (MGO) and the TRPA1 channel in inducing astrocyte senescence and neurodegeneration, Natalie Hill

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Fungi Associated with Herbaceous Plants in Coastal Northern California, Greg Huffman

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Mechanisms of how diet and light interact to influence Drosophila longevity through the eye, Charles H. Lau

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Advancing the Preclinical Development of Secondary Metabolites from Cacospongia mycofijiensis for the Treatment of Cancer, Joseph Morris

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Expanding the understanding of viral tropism by characterizing the N-glycomic profiles of transducible cell lines and tissue types and Characterizing functional receptors that mediate the inhibitory relationship between 4-O-sulfated chondroitin sulfate and neurons, Jorden Tahquechi

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Investigating the Human-mouse Interspecies Barrier to AAV-driven Gene Therapy Using a Mouse with a Humanized Liver, Slesha Thapa

Theses/Capstones from 2020

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Neuroprotection against Alzheimer’s and lifespan extension induced by dietary restriction are associated with metabolomic changes and depend on oxidative resistance protein 1 (OXR1), George W. Brownridge III

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Identifying New Markers and Mechanisms of Mitochondrial Defect During Aging, Catherine Chang

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Elucidating the Effects of Glucose Toxicity on Tauopathy and Aging, Lukas Fluitt

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Model Characterization of Pulmonary Arterial Hypertension: Analysis of Lung Pathology with Respect to Human Disease, Eptisam Lambu

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Modulating Matrix Metalloproteases and Inflammation in Huntington’s Disease, Alejandro Lopez Ramirez

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NF-L as a Readout for Disease Progression and Rescue, Isaac Villalpando

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Determining the link between advanced glycation endproducts (AGEs), feeding, and metabolism, Lauren Wimer

Theses/Capstones from 2019

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GM2 Gangliosidosis Natural History Study: Sandhoff Feline and Tay-Sachs Sheep And Evaluation of different bead coupling chemistries for immobilizing GAG chains to produce affinity resins to discover GAG-binding proteins important for neuroregeneration after central nervous system injury, Catlyn Cavender