Development and organization of the hypophysiotropic hypothalamus driving the pituitary-gonadal axis in the rhesus monkey

Authors

Tony M. Plant, Department of Cell Biology and Physiology, University of Pittsburgh School of MedecineFollow
Mohammed El Majdoubi, Department of Cell Biology and Physiology, University of Pittsburgh School of MedecineFollow
A. R. Durrant, Department of Cell Biology and Physiology, University of Pittsburgh School of Medecine
Abhiram Sahu, Department of Cell Biology and Physiology, University of Pittsburgh School of MedecineFollow

Document Type

Article

Source

Annales d'Endocrinologie

ISSN

0003-4266

Volume

60

Issue

2

First Page

60

Last Page

66

Publication Date

7-1999

Department

Natural Sciences and Mathematics

Abstract

Abstract

Le but de cette revue est de décrire, tout particulièrement chez le singe rhésus, l'ontogenèse et l'organisation fonctionnelle du générateur de pulse à GnRH au niveau de l'hypothalamus. Cette fonction est assurée chez les primates, par un groupe d'environ 1 000 neurones répartis diffusément dans l'ensemble de l'hypothalamus. Le GnRH, initialement produit sous forme d'une préhormone, est déversé dans la circulation porte-hypothalamo-hypophysaire et va permettre la libération de FSH et LH.

Abstract

The purpose of the present review is to describe, with particular emphasis on the rhesus monkey, the ontogeny and functional organisation of the hypothalamic GnRH pulse generator. Control of pituitary-gonadal axis in higher primates is provided by a group of some 1,000 GnRH neurons that are diffusely distributed throughout the hypothalamus. After synthesis of a prehormone and formation of the mature decapeptide, GnRH is released in the hypophysial portal circulation and stimulates FSH and LH production.

Rights

Copyright © 1999 Elsevier Masson SAS. Tous droits réservés.

PubMed ID

10456175

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.