Publication Year

2023

Degree Name

Master of Science in Physician Assistant Studies

Department

Physician Assistant Studies

Program Director

Jennifer Wurz

Literature Review Advisor

Maria DeSousa

Abstract

Mesenchymal stem cell (MSC) therapies have been growing in popularity in research due to their anti-inflammatory, immunomodulatory, and regenerative properties. Many ongoing clinical trials are investigating the safety and efficacy of MSC therapies to treat osteoarthritis, also known as “wear and tear” arthritis. As the average life expectancy increases, with age people are more prone to developing this disease, therefore, increasing its prevalence. This condition is progressive and will lead to functional decline, decreased quality of life, and increased medical costs. Our focus is to discuss the efficacy of mesenchymal stem cell injections in alleviating pain, improving functionality, and slowing the disease progression of osteoarthritis in adults. We systematically reviewed studies through multiple databases, including PubMed, ScienceDirect, AccessMedicine, and Iceberg using the search terms mesenchymal stem cells, osteoarthritis, stem cell therapy, and degenerative joint disease. We limited searches to 2018 and newer, studies in English, and human trials. A total of 20 studies that met the criteria out of 65 full-text studies were included in this review. Clinical outcomes such as pain, functionality, and tissue regeneration were assessed using WOMAC, KOOS, and other validated clinical outcome scales, and resonance imaging were used for disease progression rating. Studies reviewing mesenchymal stem cell injections in arthritic joints have shown positive clinical outcomes with results showing pain level, joint function and regeneration. To realize stem cell injections outside of studies, long-term and larger-scale randomized clinical trials are required to strengthen the interpretations and validity of current studies.

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