Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors

Patrick C. Still, University of California, Santa CruzFollow
Tyler A. Johnson, University of California, Santa CruzFollow
Christine M. Theodore, University of California, Santa CruzFollow
Steven T. Loveridge, University of California, Santa CruzFollow
Phillip Crews, University of California, Santa CruzFollow

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Journal of Natural Products

Publication Date

3-28-2014

ISSN

1520-6025

Volume

77

Issue

3

First Page

690

Last Page

702

Abstract

Compounds from macro marine organisms are presumed to owe their biosynthetic origins to associated microbial symbionts, although few definitive examples exist. An upsurge in the recent literature from 2012 to 2013 has shown that four compounds previously reported from macro marine organisms are in fact biosynthesized by non-photosynthetic Gram-negative bacteria (NPGNB). Structural parallels between compounds isolated from macro marine organisms and NPGNB producers form the basis of this review. Although less attention has been given to investigating the chemistry of NPGNB sources, there exists a significant list of structural parallels between NPGNB and macro marine organism-derived compounds. Alternatively, of the thousands of compounds isolated from Gram-positive actinomycetes, few structural parallels with macro marine organisms are known. A summary of small molecules isolated from marine NPGNB sources is presented, including compounds isolated from marine myxobacteria. From this assemblage of structural parallels and diverse chemical structures, it is hypothesized that the potential for the discovery of inspirational molecules from NPGNB sources is vast and that the recent spike in the literature of macro marine compounds owing their biosynthetic origin to NPGNB producers represents a turning point in the field.

PubMed ID

24571234

Comments

Dedicated to Prof. Dr. Otto Sticher, of ETH-Zurich, Zurich, Switzerland, for his pioneering work in pharmacognosy and phytochemistry.

Rights

Copyright © 2014 The American Chemical Society and American Society of Pharmacognosy

Publisher's Statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher.