A reassignment of (-)-mycothiazole and the isolation of a related diol.

Authors

Rachel N. Sonnenschein, University of California, Santa Cruz, California, USA
Tyler A. Johnson, University of California, Santa Cruz, California, USAFollow
Karen Tenney, University of California, Santa Cruz, California, USAFollow
Frederick A. Valeriote, University of California, Santa Cruz, California, USA
Phillip Crews, University of California, Santa Cruz, California, USAFollow

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Journal of Natural Products

Publication Date

1-1-2006

ISSN

0163-3864

Volume

69

Issue

1

First Page

145

Last Page

147

Abstract

A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.

PubMed ID

16441088

Rights

Copyright © 2006 American Chemical Society and American Society of Pharmacognosy

Publisher's Statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher.