Graduation Date
5-2018
Document Type
Master's Thesis
Degree Name
Master of Science
Department or Program
Biological Sciences
Department or Program Chair
Meredith Protas, PhD
First Reader
Maggie Louie, PhD
Second Reader
Kristylea Ojeda, PhD
Abstract
Hypophosphatemic rickets is a rare, renal phosphate wasting disorder that presents various skeletal deformities. Although there are specific clinical presentations and biochemical findings used to identify hypophosphatemic rickets, there are various underlying renal phosphate wasting disorders that can lead to hypophosphatemic rickets making diagnosis extremely difficult. A targeted literature review through electronic search engines (e.g., BMC, PubMed, Google Scholar) was conducted to: 1) consolidate and summarize currently available data regarding the various renal phosphate wasting disorders, 2) identify current obstacles of successful diagnosis and treatment, and 3) propose directions for future hypophosphatemic rickets research into new biomarkers.