Document Type
Conference Proceeding
Source
American Society of Tropical Medicine and Hygiene 64th Annual Meeting
Location
Philadelphia, PA
Publication Date
10-25-2015
Department
Natural Sciences and Mathematics
Abstract
- Artemisinin-‐based combination therapy is now standard treatment for falciparum malaria. However, this regimen is threatened by resistance to artemisinins, manifest as delayed clearance of parasitemia after therapy, in southeast Asia.
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Artemisinin resistance in southeast Asia is associated with increased parasitemias in culture, compared to those in sensi0ve parasites, 72 hours a=er a 6 hour pulse with 700 nM dihydroartemisinin (DHA), and with propeller domain polymorphisms in the Plasmodium falciparum kelch (K13; PF3D7_1343700) gene
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Given that artemether/lumefantrine has been adopted as standard therapy for malaria within the last decade in Uganda, we characterized artemisinin sensiBvity in fresh P. falciparum isolates from Kampala using ex vivo ring-‐stage survival and IC50 assays. We also assessed the K13 gene for polymorphisms.
Comments
Presented at American Society of Tropical Medicine and Hygiene 64th Annual Meeting. Oct. 25-29, 2015. Philadelphia, PA, USA