Document Type

Article

Journal or Conference Title

Antimicrobial Agents and Chemotherapy

ISSN

0066-4804

Volume

59

Issue

8

First Page

5061

Last Page

5064

Publication Date

8-2015

Department

Natural Sciences and Mathematics

Abstract

We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures at 72 h. Two of 53 isolates had nonsynonymous K13-propeller gene polymorphisms but did not have the mutations associated with resistance in Asia. Thus, we did not see evidence for artemisinin resistance in Uganda.

Rights

Copyright 2015 ©, American Society for Microbiology. All rights reserved.

Publisher Statement

Originally published as Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL, Rosenthal PJ. 2015. Lack of artemisinin resistance in Plasmodium falciparum in Uganda based on parasitological and molecular assays. Antimicrob Agents Chemother 59:5061–5064.

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