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Multiple sclerosis (MS) is a condition that causes cognitive and physical fatigue, which can slow cognitive processing speed (CPS). Slow CPS affects occupational engagement. Evidence suggests that physical activity can be used as an intervention to address and manage slowed CPS in MS. This Level I randomized controlled trial (RCT) examined the impact of a physical-activity behavioral intervention on CPS and walking performance among people with mild to moderate MS.

Seventy-six participants with mild to moderate MS participated in the study for 6 months. The participants were split into two groups, the intervention group and the wait-list control group. In the intervention group, participants were provided a social–cognitive theory (SCT) program for increasing physical activity through a website and one-on-one video behavioral-coaching sessions. The main intention of this SCT program was to increase ambulatory physical activity by teaching the behavioral strategies of self-monitoring, goal setting, and goal attainment.


A product of the American Occupational Therapy Association's Evidence-based Literature Review Project.


Copyright © 2016 American Occupational Therapy Association. All Rights Reserved. Reproduced here with permission.

Publisher's Statement

Originally published as Chaffee, E., Duong, T., Gothelf, K., Minor, E., & Li, K. (2018). Critically Appraised Paper for “Adaptive vs. non-adaptive cognitive training by means of a personalized App: A randomized trial in people with multiple sclerosis.” Journal of NeuroEngineering and Rehabilitation, 13(1), 88. Bethesda, MD: American Occupational Therapy Association, Evidence-Based Practice Project.