The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells.

Authors

Nicholas Lorig-Roach, University of California, Santa Cruz, California, USAFollow
Frances Hamkins-Indik, University of California, Santa Cruz, California, USA
Tyler A. Johnson, University of California, Santa Cruz, California, USAFollow
Karen Tenney, University of California, Santa Cruz, California, USAFollow
Frederick A. Valeriote, Henry Ford Hospital, Detroit, Michigan, USA
Phillip Crews, University of California, Santa CruzFollow

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Tetrahedron

Publication Date

1-11-2018

ISSN

0040-4020

Volume

74

Issue

2

First Page

217

Last Page

223

Abstract

Our quest to isolate and characterize natural products with in vitro solid tumor selectivity is driven by access to repositories of Indo-Pacific sponge extracts. In this project an extract of a species of Haplosclerida sponge obtained from the US NCI Natural Products Repository displayed, by in vitro disk diffusion assay (DDA) and IC

PubMed ID

29576661

Rights

© 2017 Elsevier Ltd. All rights reserved.