Title

A reassignment of (-)-mycothiazole and the isolation of a related diol.

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Journal of Natural Products

Publication Date

1-1-2006

ISSN

0163-3864

Volume

69

Issue

1

First Page

145

Last Page

147

Digital Object Identifier / DOI

https://doi.org/10.1021/np0503597

Abstract

A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.

PubMed ID

16441088

Rights

Copyright © 2006 American Chemical Society and American Society of Pharmacognosy

Publisher's Statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher.

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