A reassignment of (-)-mycothiazole and the isolation of a related diol.
Digital Object Identifier / DOI
Natural Sciences and Mathematics
Journal of Natural Products
A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.
Copyright © 2006 American Chemical Society and American Society of Pharmacognosy
This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher.