Title

The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis.

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Organic Letters

Publication Date

5-7-2009

ISSN

1523-7052

Volume

11

Issue

9

First Page

1975

Last Page

1978

Digital Object Identifier / DOI

https://doi.org/10.1021/ol900446d

Abstract

A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensis has yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1-3 were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness.

PubMed ID

19385671

Rights

Copyright © 2009 American Chemical Society

Publisher's Statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher.

Share

COinS