Title

Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola.

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Organic Letters

Publication Date

10-15-2010

ISSN

1523-7052

Volume

12

Issue

20

First Page

4458

Last Page

4461

Digital Object Identifier / DOI

https://doi.org/10.1021/ol101396n

Abstract

Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.

PubMed ID

20866076

Rights

Copyright © 2010 American Chemical Society

Publisher's Statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher.

Share

COinS