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Cyclooxygenase-2 (COX-2) is an enzyme that helps catalyze the formation of prostaglandins, which promote inflammation, pain, and fever and maintain other normal physiological functions throughout the body. However, the overexpression of COX-2 has been found to play a role in various diseases including breast cancer. COX-2 exists as two major glycoforms— 72 kDa and 74 kDa— due to the glycosylation site Asn580 which is glycosylated 50% of the time. Past studies from our lab have shown that this glycosylation regulates COX-2 protein turnover in the cell3. The proteins E-cadherin— a tumor suppressor— and β-catenin— a tumor driver— can be regulated by COX-2 activity
Natural Sciences and Mathematics
Experimental Biology Meeting, virtual conference
COX-2, Cancer, Cyclooxygenase-2, Breast Cancer
Biology | Cancer Biology | Cell and Developmental Biology
Roan, Genna; Alexander, Grace; Cruz, Klarisse; Nguyen, Janelle; and Sevigny, Mary B., "Effect of Cyclooxygenase-2 Glycosylation on Downstream Expression of E-Cadherin and β-Catenin in MCF-7 Breast Cancer Cells" (2021). Natural Sciences and Mathematics | Faculty Research Posters. 3.