Project Title

Celiac Test Assay Comparison: Bio-Rad Autoimmune EIA Anti-Tissue Transglutaminase (tTG) IgA and IgG Tests on the Inova Quanta-Lyser 240 vs. BioPlex 2200 Celiac IgA and IgG Kits for Use at a Large Reference Laboratory

Graduation Date


Document Type

Culminating Project

Degree Name

Master of Science


Clinical Laboratory Sciences

Program Director

Mary Sevigny, PhD

Faculty Advisor

Howard Koo

Project Supervisor

James LaPan


As awareness of Celiac disease grows, testing services offered by clinical laboratories must expand accordingly. Testing needs at large reference laboratories are especially impacted by this change due to their coverage of broad geographic range and diverse patient populations. For this reason, traditional Celiac testing methods have given way to new technologies that offer greater flexibility and performance. A comprehension of the pathogenesis of this disease helps to explain how diagnostic workup for this disease has evolved. Likewise, an understanding of current diagnostic testing options can offer some insight into the optimization of quality laboratory services in the interest of improving Celiac patient outcomes.

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