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Theses/Capstones from 2018

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Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability, Mariah Alejo

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Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy, Beatrice Becker

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Chronic cadmium exposure alters ERα dependency and drug sensitivity of breast cancer cells, Mathew Bloomfield

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Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease, Monica Buselli

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Engineering functionalized beta-cyclodextrins to improve cholesterol clearance in Niemann-Pick type C disease cells, Rena Chan

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Best Practices in a Clinical Development Project Management Office (PMO) to Achieve a Reference Standard in the Pharmaceutical Industry, Russell Guinto

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Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans, Austin Lim

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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease, Kuruwitage Madushani

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Hypophosphatemic Rickets: A Targeted Literature Review to Characterize the Multiple Causes of Phosphate Wasting Disorders and Identify Potential Disease Biomarkers, Christopher O'Mara

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Combinational Therapy to Mitigate α-Dicarbonyl Toxicity, Jessica Ramirez

Theses/Capstones from 2017

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Mammalian Cell Line Development Platform for Recombinant Protein Production: Expanding the Protein Expression Toolbox for Research and Drug Discovery Applications, Elizabeth Del Greco

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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases, Sana Khateeb

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The Developmental and Genetic Basis of Differences in Cave and Surface-dwelling Forms of the Crustacean, Asellus aquaticus, Hafasa Mojaddidi

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Modeling 3D Retinogenesis in Mouse Embryonic Stem Cells Following CRISPR-mediated Crx Knockdown, Pooja Prasad

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Changing Antimalarial Drug Sensitivities in Uganda, Stephanie Alexis Rasmussen

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Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster, Jesse Simons

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The Effects of Various Therapeutics on Cystine Stone Formation, See Yang

Theses/Capstones from 2016

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Transgenerational epigenetic inheritance via environmental stress in Caenorhabditis elegans, Monica A. Arroliga

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Evaluating the Performance of in Silico Predictive Models on Detecting Splice-altering Variants, Erica Cayton

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Optimizing Pharmacological Lifespan Extension: Testing Chemical Compounds for Additive Effects on Longevity, Elizabeth Chao

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Induction of Human Embryonic stem cell derived retinal stem cells in vitro using transient overexpression of messenger RNA for BLIMP, ONECUT1 and OTX2, Helen Cifuentes

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Inhibition of MCF-7 Breast Cancer Cell Proliferation by Diarylthiourea Analogs, Maryam Fallatah

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Synaptic Homeostasis at the Drosophila Neuromuscular Junction: Molecular Mechanisms and Developmental Adaptation, Lindsay A. Gray

Exploring the Role of Oxytocin Signaling in Aging Using Caenorhabditis elegans, Kandyce M. Hamilton

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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity, Adam A. Kinion