Dominican University of California
 

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Presentation or Panel Title

Huntington's Disease and Stem Cells

Location

Guzman 114

Start Date

4-15-2016 2:35 PM

End Date

4-15-2016 3:00 PM

Department

Natural Sciences and Mathematics

Student Type

Undergraduate - Honors

Faculty Mentor

Kiowa Bower, Ph.D.

Presentation Format

Oral Presentation

Abstract/Description

Huntington's Disease (HD) is a progressive neurodegenerative disease with significant psychiatric and physical effects. We first began by implementing cell passaging procedures with both embryonic stem cells (ESCs) and neural stem cells (NSCs). Further, my thesis includes a synopsis of prior research to date regarding the overview of HD and epidemiology. Finally, in this study we use neural stem cells (NSCs) as a model of HD. The Huntingtin in one cell lines contains 140 glutamine repeats (140Q) while the “wildtype” control cells are 7Q. Our results conclude the difference between a healthy and HD-affected NSC.

Comments

I worked with Matthew Erbst in this research so while similar, he focused more on the molecular aspect within a chapter.

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Apr 15th, 2:35 PM Apr 15th, 3:00 PM

Huntington's Disease and Stem Cells

Guzman 114

Huntington's Disease (HD) is a progressive neurodegenerative disease with significant psychiatric and physical effects. We first began by implementing cell passaging procedures with both embryonic stem cells (ESCs) and neural stem cells (NSCs). Further, my thesis includes a synopsis of prior research to date regarding the overview of HD and epidemiology. Finally, in this study we use neural stem cells (NSCs) as a model of HD. The Huntingtin in one cell lines contains 140 glutamine repeats (140Q) while the “wildtype” control cells are 7Q. Our results conclude the difference between a healthy and HD-affected NSC.