Document Type

Conference Proceeding

Journal or Conference Title

American Society of Tropical Medicine and Hygiene 64th Annual Meeting

Location

Philadelphia, PA

Publication Date

10-25-2015

Department

Natural Sciences and Mathematics

Abstract

  • Artemisinin-­‐based combination therapy is now standard treatment for falciparum malaria. However, this regimen is threatened by resistance to artemisinins, manifest as delayed clearance of parasitemia after therapy, in southeast Asia.
  • Artemisinin resistance in southeast Asia is associated with increased parasitemias in culture, compared to those in sensi0ve parasites, 72 hours a=er a 6 hour pulse with 700 nM dihydroartemisinin (DHA), and with propeller domain polymorphisms in the Plasmodium falciparum kelch (K13; PF3D7_1343700) gene

  • Given that artemether/lumefantrine has been adopted as standard therapy for malaria within the last decade in Uganda, we characterized artemisinin sensiBvity in fresh P. falciparum isolates from Kampala using ex vivo ring-­‐stage survival and IC50 assays. We also assessed the K13 gene for polymorphisms.

Comments

Presented at American Society of Tropical Medicine and Hygiene 64th Annual Meeting. Oct. 25-29, 2015. Philadelphia, PA, USA

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